If you have been searching for natural ways to support your hormonal health, progesterone cream might already be on your radar. This topical solution has gained popularity among women seeking relief from hormonal fluctuations, whether during their menstrual cycle, perimenopause, or menopause. Understanding how to use progesterone cream correctly can make all the difference in achieving the results you are hoping for.
Progesterone cream offers a convenient way to deliver this essential hormone through your skin, allowing for gradual absorption into your bloodstream. Unlike oral supplements, topical progesterone bypasses the digestive system, potentially offering more consistent hormone levels throughout the day. This guide will walk you through everything you need to know about using progesterone cream safely and effectively.
What Is Progesterone Cream and How Does It Work?
Progesterone cream is a topical formulation containing bioidentical progesterone, a hormone that mirrors the molecular structure of the progesterone your body produces naturally. When applied to your skin, the cream allows progesterone to absorb through the dermal layers and enter your bloodstream, helping to restore hormonal balance. Products like Menopause SOS Cream contain carefully formulated ingredients that support this absorption process whilst nourishing your skin.
The transdermal delivery method offers several advantages. Your skin acts as a natural reservoir, slowly releasing progesterone throughout the day. This gradual release helps maintain more stable hormone levels compared to other delivery methods, which can lead to more consistent symptom relief.
6 Common Uses for Progesterone Cream
Women turn to progesterone cream for various reasons related to hormonal health. Here are the most common applications:
PMS Relief
Many women experience relief from premenstrual symptoms when using progesterone cream during the luteal phase. Research published in the journal Pharmaceuticals indicates that progesterone and its metabolites play a significant role in modulating symptoms associated with the menstrual cycle through their effects on neurotransmitter systems. The Period SOS Cream is specifically designed to address these cyclical concerns with its blend of wild yam and vitex.
Perimenopause Support
During perimenopause, progesterone levels often decline before oestrogen, creating an imbalance that can cause uncomfortable symptoms. Clinical research in the Climacteric journal demonstrates that oral micronised progesterone effectively treats vasomotor symptoms in menopausal women, with one randomised controlled trial showing a 55% decrease in hot flushes and night sweats. Topical progesterone cream can help restore balance during this transitional phase.
Menopause Symptom Management
Post-menopausal women may use progesterone cream to address symptoms such as hot flushes, night sweats, and vaginal dryness. A placebo-controlled randomised trial published in the Menopause journal found that progesterone at 300mg daily significantly reduced vasomotor symptoms compared to placebo in healthy postmenopausal women. The Menopause SOS Cream combines progesterone-supporting botanicals to help ease this transition naturally.
Sleep Improvement
Progesterone has natural sedative properties that can support better sleep quality. Research published in Psychopharmacology demonstrates that progesterone induces changes in sleep comparable to those of GABA-A receptor modulators, promoting deeper, more restorative sleep. For enhanced relaxation support, pairing progesterone cream with the Super Rich Magnesium Body Lotion can provide comprehensive sleep support.
Mood Stabilisation
Hormonal fluctuations can significantly impact mood and emotional well-being. Studies in the Journal of Steroid Biochemistry have shown that allopregnanolone, a metabolite of progesterone, has anxiolytic effects mediated through GABA-A receptors in the brain. This mechanism helps explain why balanced progesterone levels are associated with improved mood stability and reduced anxiety.
Bone Health Support
Emerging research suggests progesterone may play a role in maintaining bone density. A systematic review and meta-analysis in the Menopause journal found that oestrogen-progestin therapy causes significantly greater increases in spinal bone mineral density than oestrogen therapy alone. This suggests progesterone has independent bone-building effects, potentially through stimulating osteoblast activity.
When to Apply Progesterone Cream: Timing Guidelines
The timing of progesterone cream application depends largely on your life stage and specific needs:
For menstruating women: Apply progesterone cream during the luteal phase, typically from day 14 to day 28 of your cycle (or from ovulation until your period begins). This mirrors your body's natural progesterone production pattern. The Period SOS Cream works particularly well when used during this phase.
For perimenopausal women: If you still have periods, follow the menstruating women's schedule. If periods have become irregular, many practitioners recommend using the cream for 21 days, followed by a 7-day break.
For post-menopausal women: You may use progesterone cream continuously or follow a 25-day-on, 5-day-off schedule. The Menopause SOS Cream provides targeted support during this stage.
Time of day: Many women find applying progesterone cream at bedtime beneficial, as it can support sleep quality. However, splitting the dose between morning and evening may provide more stable hormone levels throughout the day.
Ready to Support Your Hormonal Health?
Whether you are navigating PMS, perimenopause, or menopause, finding the right support can make all the difference. Explore Glow by Hormone University's range of hormone-supporting creams to discover natural solutions designed specifically for women at every hormonal stage. From the Period SOS Cream for cyclical support to the Menopause SOS Cream for menopausal transitions, you will find clean, effective formulations that work with your body's natural rhythms.
Frequently Asked Questions H
1. How long does it take for progesterone cream to work?
Most women begin noticing effects within 2-3 weeks of consistent use, though some experience benefits sooner. Full hormonal balancing may take 2-3 months of regular application.
2. Can I use progesterone cream with other skincare products?
Yes, but apply progesterone cream first on clean skin and allow it to absorb fully before applying other products. Avoid applying other creams or oils to the same area immediately.
3. Are there any side effects of progesterone cream?
Some women may experience initial drowsiness, breast tenderness, or changes in their menstrual cycle. These effects typically subside as your body adjusts. If symptoms persist, consult your healthcare provider.
4. Should I take a break from using progesterone cream?
For menstruating women, natural breaks occur during menstruation. Post-menopausal women may benefit from periodic breaks (5-7 days per month) to prevent receptor down-regulation and maintain sensitivity to the hormone.
5. Is progesterone cream safe for long-term use?
Bioidentical progesterone cream is generally considered safe for extended use when applied appropriately. However, regular check-ins with your healthcare provider are recommended to monitor your hormone levels and overall health.

